Madhumathi (Genelia D'Souza) is the daughter of a politician who turns out to be a martinet at home with his attachment on power. He affirms that the behavior of his daughter would influence on his caste politics. Hence he keeps on abstaining her from continuing her MBBS as she goes to college and moves with friends of different mentalities. However, Madhumathi, comes to third year of medicine by maintaining her dignity and without involving in any affairs of love. Her focus would be completely on studies. Once, she goes for a medical camp along with her class mates. She meets Bunny (Allu Arjun) there who happens to be an orphan (in fact, he has nothing to do with medical college students). The story starts with his funny and playful encounters with Madhumathi.
However, Bunny comes to Hyderabad and joins in a Pizza Shop as a delivery boy and continuous his MBA by attending evening classes.
In an incident, Madhumathi’s father doubts that his daughter is missing the track and getting wooed with Bunny. Hence he decides to get her married to a person of his own caste who settled in a top position. He is Manoj Bajpai, the Deputy Commissioner of Police.
Genelia is more attached to her studies than the marriage. Knowing that, Bunny plans to stop the marriage and meets the DCP. Bunny acts before him and gives a false communication that he is in love with Madhumathi. But the story takes other way round. Manoj Bajpai believes Bunny’s words and gets him married to Madhumathi in a forcible Register Marriage. He also gives his new flat for the couple to live in. Madhumathi loses connection with her family and lives with Bunny. The comedy track between Madhumathi and Bunny is pictured interestingly. Bunny also gets into film industry as a stuntman taking high risk to his life to pay the semester fees of Madhumathi’s MBBS.
But Madhumathi scores less in a subject and gets a negative feedback from her professor. Simply to focus on her studies, she keeps away from Bunny that makes the latter worried. Madhumathi receives the MBBS degree at last. She tries to meet Bunny but he goes far away from her. Madhumathi tries to meet him with all grief. Rest of the story is how they get united.